Identification and Characterization of a Functional TATA Box Polymorphism of the UDP Glucuronosyltransferase 1A7 Gene
نویسندگان
چکیده
منابع مشابه
Identification and characterization of a functional TATA box polymorphism of the UDP glucuronosyltransferase 1A7 gene.
UDP glucuronosyltransferases (UGT) detoxify bilirubin and therapeutic drugs, a process influenced by single nucleotide polymorphisms (SNPs) in their structural genes and promoter elements. UGT1A1*28 is a functional UGT promoter polymorphism associated with Gilbert's disease and severe irinotecan toxicity, which also occurs in the absence of UGT1A1*28. The aim of this study was to identify and c...
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ژورنال
عنوان ژورنال: Molecular Pharmacology
سال: 2005
ISSN: 0026-895X,1521-0111
DOI: 10.1124/mol.104.007146